Red Light Therapy for Abdominal aortic aneyrusm

After acute myocardial infarction and stroke, the rupture of abdominal aortic aneurysm is a relatively common cause of cardiovascular death. In three mouse studies of angiotensin II subcutaneous infusion for apo-E deficient mice, PBM (780 nm; ~2 J/cm2; 9 min irradiation; ~1 month study) has shown effectiveness in preventing development of abdominal aortic aneurysm and arresting further progression of pre-induced aneurysm (Gavish et al. 2014, Gavish et al. 2012, Gavish et al. 2009). Human trials haven't been conducted so far. Light would not reach the aneurysm via skin irradiation, and thus, light delivery via femoral artery, abdomen or transverse colon has been suggested (Gavish et al. 2022).